4Q01
Second-site screening of K-Ras in the presence of covalently attached first-site ligands
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | K-Ras | polymer | 169 | 19313.8 | 2 | UniProt (P01116) Pfam (PF00071) | Homo sapiens | |
| 2 | C, F (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 3 | D, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, H (A, B) | naphthalene-1-thiol | non-polymer | 160.2 | 2 | Chemie (2XH) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 434 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Val 12 | Gly 12 | engineered mutation |
| Cys 39 | Ser 39 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38627.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1255.5 | |
| All* | Total formula weight | 39883.2 |
