4PZ4
High-resolution crystal structure of the human CD44 hyaluronan binding domain in new space group
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | CD44 antigen | polymer | 154 | 17047.0 | 2 | UniProt (P16070) Pfam (PF00193) | Homo sapiens (human) | CDw44, Epican, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I |
| 2 | C, D, E, K, L... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 3 | F, J, M, R (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 4 | G (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | H, I, O, P (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 6 | Q (B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 7 | S, T (A, B) | water | water | 18.0 | 199 | Chemie (HOH) |
Sequence modifications
A, B: 18 - 171 (UniProt: P16070)
| PDB | External Database | Details |
|---|---|---|
| Ala 18 | Ser 18 | engineered mutation |
| Met 19 | Leu 19 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34094.1 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1419.4 | |
| All* | Total formula weight | 35513.4 |
