4PZ3
High-resolution crystal structure of the human CD44 hyaluronan binding domain complex with undefined peptides
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | CD44 antigen | polymer | 153 | 16960.0 | 2 | UniProt (P16070) Pfam (PF00193) | Homo sapiens (human) | CDw44, Epican, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I |
| 2 | C (C) | Undefined peptides modeled as AAAV | polymer | 4 | 330.4 | 1 | Escherichia coli | ||
| 3 | D (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | E, G (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | F (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 6 | H, I, J (A, B, C) | water | water | 18.0 | 372 | Chemie (HOH) |
Sequence modifications
A, B: 18 - 170 (UniProt: P16070)
| PDB | External Database | Details |
|---|---|---|
| Ala 18 | Ser 18 | engineered mutation |
| Met 19 | Leu 19 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 34250.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 425.5 | |
| All* | Total formula weight | 34675.8 |
