4PWQ

HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE E1-DOMAIN of THE AMYLOID PRECURSOR PROTEIN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	Amyloid beta A4 protein	polymer	191	21762.1	2	UniProt (P05067) Pfam (PF02177) Pfam (PF12924) In PDB	Homo sapiens (human)	ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), C31
2		water	water		18.0	624	Chemie (HOH)

Sequence modifications

B, A: 18 - 190 (UniProt: P05067)

PDB	External Database	Details
Met 17	-	EXPRESSION TAG
Ile 191	-	EXPRESSION TAG
Glu 192	-	EXPRESSION TAG
Gly 193	-	EXPRESSION TAG
Arg 194	-	EXPRESSION TAG
Lys 195	-	EXPRESSION TAG
Leu 196	-	EXPRESSION TAG
Ala 197	-	EXPRESSION TAG
Ala 198	-	EXPRESSION TAG
Ala 199	-	EXPRESSION TAG
Leu 200	-	EXPRESSION TAG
Glu 201	-	EXPRESSION TAG
His 202	-	EXPRESSION TAG
His 203	-	EXPRESSION TAG
His 204	-	EXPRESSION TAG
His 205	-	EXPRESSION TAG
His 206	-	EXPRESSION TAG
His 207	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	43524.2
All*	Total formula weight	43524.2

*Water molecules are not included.