4PWQ

HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE E1-DOMAIN of THE AMYLOID PRECURSOR PROTEIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008201	molecular_function	heparin binding
A	0016020	cellular_component	membrane
A	0046914	molecular_function	transition metal ion binding
B	0008201	molecular_function	heparin binding
B	0016020	cellular_component	membrane
B	0046914	molecular_function	transition metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00319
Number of Residues	8
Details	APP_CUBD Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. GVEFVCCP

Chain	Residue	Details
B	GLY181-PRO188

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8158260

Chain	Residue	Details
B	ASN96
A	ASN96

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1

Chain	Residue	Details
B	HIS147
B	HIS151
A	HIS147
A	HIS151

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0007744|PDB:2FK1

Chain	Residue	Details
B	TYR168
A	TYR168

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site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305|PubMed:8344894

Chain	Residue	Details
B	GLU183
B	CYS186
B	CYS187
A	GLU183
A	CYS186
A	CYS187

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site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: Required for Cu(2+) reduction => ECO:0000255|PROSITE-ProRule:PRU01217

Chain	Residue	Details
B	MET170
A	MET170

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