4PV0
Crystal structure of spleen tyrosine kinase (Syk) in complex with an imidazopyrazine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase SYK | polymer | 275 | 31855.7 | 1 | UniProt (P43405) Pfam (PF07714) | Homo sapiens (human) | Spleen tyrosine kinase, p72-Syk |
| 2 | B (A) | 4-[(3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzoyl)amino]benzoic acid | non-polymer | 509.5 | 1 | Chemie (CG4) | |||
| 3 | C, D, E, F, G (A) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 4 | H (A) | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A: 363 - 635 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| Glu 636 | - | expression tag |
| Gly 637 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31855.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 686.8 | |
| All* | Total formula weight | 32542.5 |
