4PSX

Crystal structure of histone acetyltransferase complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Histone acetyltransferase type B catalytic subunit	polymer	320	37566.3	2	UniProt (Q12341) Pfam (PF10394) Pfam (PF00583) Pfam (PF21184) In PDB	Saccharomyces cerevisiae (Baker's yeast)
2	B, E	Histone acetyltransferase type B subunit 2	polymer	401	45107.9	2	UniProt (P39984) Pfam (PF12265) Pfam (PF00400) In PDB	Saccharomyces cerevisiae (Baker's yeast)
3	C, F	Histone H4	polymer	48	5093.1	2	UniProt (P02309) Pfam (PF15511) In PDB	Saccharomyces cerevisiae (Baker's yeast)
4	Y, P	Histone H3	polymer	15	1565.8	2	UniProt (P61830) In PDB	Saccharomyces cerevisiae S288c (Baker's yeast)
5	A, D	COENZYME A	non-polymer		767.5	2	Chemie (COA)
6	B	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
7		water	water		18.0	606	Chemie (HOH)

Sequence modifications

A, D: 7 - 319 (UniProt: Q12341)

PDB	External Database	Details
Met 1	-	expression tag
Ser 2	-	expression tag
Ala 3	-	expression tag
Asn 4	-	expression tag
Asp 5	-	expression tag
Phe 6	-	expression tag
Ser 320	-	expression tag

B, E: 8 - 389 (UniProt: P39984)

PDB	External Database	Details
Met 1	-	expression tag
Glu 2	-	expression tag
Asn 3	-	expression tag
Gln 4	-	expression tag
Glu 5	-	expression tag
Lys 6	-	expression tag
Pro 7	-	expression tag
Thr 143	Val 143	engineered mutation
Gly 390	-	expression tag
Gly 391	-	expression tag
Pro 392	-	expression tag
Pro 393	-	expression tag
Lys 394	-	expression tag
Val 395	-	expression tag
Asn 396	-	expression tag
Lys 397	-	expression tag
Asp 398	-	expression tag
Ile 399	-	expression tag
Ile 400	-	expression tag
Ser 401	-	expression tag

C, F: 1 - 48 (UniProt: P02309)

PDB	External Database	Details
Val 21	Ile 22	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	178666.2
Non-Polymers*	Number of molecules	3
	Total formula weight	1631.1
All*	Total formula weight	180297.4

*Water molecules are not included.