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4PS5

Crystal structure of the first bromodomain of human BRD4 in complex with TG101348

Replaces:  4O73
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BBromodomain-containing protein 4polymer12715099.42UniProt (O60885)
Pfam (PF00439)
In PDB
Homo sapiens (human)Protein HUNK1
2A, BN-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamidenon-polymer524.72Chemie (2TA)
3A, B1,2-ETHANEDIOLnon-polymer62.13Chemie (EDO)
4BACETATE IONnon-polymer59.01Chemie (ACT)
5waterwater18.0297Chemie (HOH)
Sequence modifications
A, B: 44 - 168 (UniProt: O60885)
PDBExternal DatabaseDetails
Ser 42-expression tag
Met 43-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight30198.8
Non-Polymers*Number of molecules6
Total formula weight1294.6
All*Total formula weight31493.4
*Water molecules are not included.

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PDB entries from 2024-08-07

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