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4PS5

Crystal structure of the first bromodomain of human BRD4 in complex with TG101348

Replaces:  4O73
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 2TA A 201
ChainResidue
APRO82
BHOH320
APHE83
AVAL87
ALEU92
AASN140
AHOH350
AHOH356
BASP145
BMET149

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 202
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH351
AHOH411

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 2TA B 201
ChainResidue
AASP145
AMET149
BTRP81
BPRO82
BPHE83
BLEU92
BLEU94
BASN140
BHOH313

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO B 202
ChainResidue
BILE100
BILE101
BLYS102
BTHR103
BASN135
BHOH364

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO B 203
ChainResidue
BLYS72
BLYS111
BHOH342
BHOH375

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ACT B 204
ChainResidue
BSER42
BALA89
BVAL90

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues212
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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