4PO2

Crystal Structure of the Stress-Inducible Human Heat Shock Protein HSP70 Substrate-Binding Domain in Complex with Peptide Substrate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Heat shock 70 kDa protein 1A/1B	polymer	235	26278.7	2	UniProt (P08107) Pfam (PF00012) UniProt (by SIFTS) (P0DMV8)	Homo sapiens (human)	Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2, HSP70.1/HSP70.2
2	C, D (C, D)	HSP70 substrate peptide	polymer	7	786.9	2			Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2, HSP70.1/HSP70.2
3	E, G (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	F (A)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
5	H, I, J, K (A, B, C, D)	water	water		18.0	558	Chemie (HOH)

Sequence modifications

A, B: 386 - 613 (UniProt: P08107)

PDB	External Database	Details
Met 379	-	expression tag
His 380	-	expression tag
His 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag
His 385	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	54131.2
Non-Polymers*	Number of molecules	3
	Total formula weight	287.1
All*	Total formula weight	54418.3

*Water molecules are not included.