4PMP
The structure of TrkA kinase bound to the inhibitor 1-cyclopropyl-1-[3-(1,3-thiazol-2-yl)benzyl]-3-[4-(trifluoromethoxy)phenyl]urea
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | High affinity nerve growth factor receptor | polymer | 291 | 33232.4 | 1 | UniProt (P04629) Pfam (PF07714) | Homo sapiens (Human) | Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA |
| 2 | B (A) | 1-cyclopropyl-1-[3-(1,3-thiazol-2-yl)benzyl]-3-[4-(trifluoromethoxy)phenyl]urea | non-polymer | 433.4 | 1 | Chemie (31W) | |||
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D, E, F (A) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 5 | G (A) | water | water | 18.0 | 171 | Chemie (HOH) |
Sequence modifications
A: 501 - 787 (UniProt: P04629)
| PDB | External Database | Details |
|---|---|---|
| His 788 | - | expression tag |
| His 789 | - | expression tag |
| His 790 | - | expression tag |
| His 791 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33232.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 646.0 | |
| All* | Total formula weight | 33878.4 |
