4PIV

Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and GSK2194069

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Fatty acid synthase	polymer	660	71848.2	2	UniProt (P49327) Pfam (PF08242) Pfam (PF21149) Pfam (PF08659)	Homo sapiens (Human)
2	C, H (A, B)	CACODYLATE ION	non-polymer		137.0	2	Chemie (CAC)
3	D, I (A, B)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
4	E, F, J, K (A, B)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
5	G, L (A, B)	4-[4-(1-benzofuran-5-yl)phenyl]-5-{[(3S)-1-(cyclopropylcarbonyl)pyrrolidin-3-yl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one	non-polymer		428.5	2	Chemie (2W4)
6	M, N (A, B)	water	water		18.0	220	Chemie (HOH)

Sequence modifications

A, B: 1110 - 1876 (UniProt: P49327)

PDB	External Database	Details
Met 1109	-	initiating methionine
Gly 1876	Pro 1524	engineered mutation

A, B: 1877 - 2114 (UniProt: P49327)

PDB	External Database	Details
His 2115	-	expression tag
His 2116	-	expression tag
His 2117	-	expression tag
His 2118	-	expression tag
His 2119	-	expression tag
His 2120	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	143696.4
Non-Polymers*	Number of molecules	10
	Total formula weight	3006.0
All*	Total formula weight	146702.4

*Water molecules are not included.