4PIV
Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and GSK2194069
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CAC A 2201 |
| Chain | Residue |
| A | PHE1880 |
| A | CYS1881 |
| A | PRO1882 |
| A | TYR1887 |
| A | LEU1904 |
| A | TYR2015 |
| site_id | AC2 |
| Number of Residues | 29 |
| Details | binding site for residue NDP A 2202 |
| Chain | Residue |
| A | PHE1896 |
| A | THR1915 |
| A | SER1916 |
| A | ARG1917 |
| A | SER1918 |
| A | ASN1945 |
| A | SER1947 |
| A | LEU1971 |
| A | ALA1972 |
| A | VAL1973 |
| A | LYS1995 |
| A | PHE2019 |
| A | SER2020 |
| A | TYR2034 |
| A | TRP2060 |
| A | GLY2061 |
| A | ILE2063 |
| A | GLY2067 |
| A | ILE2068 |
| A | LEU2069 |
| A | 2W42205 |
| A | HOH2313 |
| A | HOH2316 |
| A | HOH2376 |
| A | HOH2396 |
| B | ARG1976 |
| A | GLY1891 |
| A | GLY1894 |
| A | GLY1895 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 2203 |
| Chain | Residue |
| A | CYS1118 |
| A | HIS2103 |
| A | MET2104 |
| A | HOH2375 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 2204 |
| Chain | Residue |
| A | ARG1206 |
| A | HIS1249 |
| A | ARG1275 |
| A | ALA1320 |
| A | ALA1321 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue 2W4 A 2205 |
| Chain | Residue |
| A | HIS1263 |
| A | PRO1264 |
| A | LEU1975 |
| A | SER2021 |
| A | SER2023 |
| A | ARG2026 |
| A | ASN2028 |
| A | TYR2034 |
| A | LEU2069 |
| A | SER2081 |
| A | THR2083 |
| A | NDP2202 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue CAC B 2201 |
| Chain | Residue |
| B | PHE1880 |
| B | CYS1881 |
| B | PRO1882 |
| B | TYR1887 |
| B | LEU1904 |
| B | TYR2015 |
| site_id | AC7 |
| Number of Residues | 27 |
| Details | binding site for residue NDP B 2202 |
| Chain | Residue |
| B | GLY1891 |
| B | GLY1894 |
| B | GLY1895 |
| B | PHE1896 |
| B | THR1915 |
| B | SER1916 |
| B | ARG1917 |
| B | SER1918 |
| B | ASN1945 |
| B | SER1947 |
| B | LEU1971 |
| B | ALA1972 |
| B | VAL1973 |
| B | LYS1995 |
| B | PHE2019 |
| B | SER2020 |
| B | TYR2034 |
| B | TRP2060 |
| B | GLY2061 |
| B | ILE2063 |
| B | GLY2067 |
| B | ILE2068 |
| B | LEU2069 |
| B | 2W42205 |
| B | HOH2310 |
| B | HOH2311 |
| B | HOH2327 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 2203 |
| Chain | Residue |
| B | CYS1118 |
| B | HIS2103 |
| B | MET2104 |
| B | HOH2393 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 2204 |
| Chain | Residue |
| B | ARG1206 |
| B | LEU1246 |
| B | HIS1249 |
| B | ARG1275 |
| B | ALA1320 |
| B | ALA1321 |
| site_id | AD1 |
| Number of Residues | 14 |
| Details | binding site for residue 2W4 B 2205 |
| Chain | Residue |
| B | HIS1263 |
| B | PRO1264 |
| B | LEU1975 |
| B | SER2021 |
| B | VAL2022 |
| B | SER2023 |
| B | ARG2026 |
| B | GLY2027 |
| B | ASN2028 |
| B | TYR2034 |
| B | VAL2080 |
| B | SER2081 |
| B | THR2083 |
| B | NDP2202 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"26851298","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
