4P7E
Triazolopyridine compounds as selective JAK1 inhibitors: from hit identification to GLPG0634
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Tyrosine-protein kinase JAK2 | polymer | 293 | 34592.4 | 2 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
| 2 | A, B | N-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | non-polymer | 425.5 | 2 | Chemie (2HB) | |||
| 3 | water | water | 18.0 | 265 | Chemie (HOH) |
Sequence modifications
A, B: 840 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Gln 1129 | Asn 1129 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69184.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 851.0 | |
| All* | Total formula weight | 70035.8 |
