4P2O
Crystal structure of the 2B4 TCR in complex with 2A/I-Ek
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | H-2 class II histocompatibility antigen, E-K alpha chain | polymer | 204 | 23618.5 | 1 | UniProt (P04224) Pfam (PF00993) Pfam (PF07654) | Mus musculus (Mouse) | |
| 2 | B (B) | MHC class II E-beta-k | polymer | 236 | 26747.8 | 1 | UniProt (Q31163) Pfam (PF00969) Pfam (PF07654) | Mus musculus (Mouse) | |
| 3 | C (C) | 2B4 T-cell receptor alpha chain | polymer | 220 | 24104.5 | 1 | Mus musculus | ||
| 4 | D (D) | 2B4 T-cell receptor beta chain | polymer | 255 | 29007.5 | 1 | Mus musculus | ||
| 5 | E (P) | 2A peptide | polymer | 22 | 2078.3 | 1 | synthetic construct | ||
| 6 | F (E) | alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 716.7 | 1 | In PDB GlyTouCan (G63564LA) | |||
| 7 | G, H, I (A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 8 | J, K, L, M, N (A, B, C, D, P) | water | water | 18.0 | 118 | Chemie (HOH) |
Sequence modifications
A: 1 - 191 (UniProt: P04224)
B: 3 - 198 (UniProt: Q31163)
| PDB | External Database | Details |
|---|---|---|
| Ala -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Ser 192 | - | expression tag |
| Arg 193 | - | expression tag |
| Gly 194 | - | expression tag |
| Gly 195 | - | expression tag |
| Leu 196 | - | expression tag |
| Glu 197 | - | expression tag |
| Val 198 | - | expression tag |
| Leu 199 | - | expression tag |
| Phe 200 | - | expression tag |
| Gln 201 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala -27 | - | expression tag |
| Asp -26 | - | expression tag |
| Pro -25 | - | expression tag |
| Ala -24 | - | expression tag |
| Asp -23 | - | expression tag |
| Pro -22 | - | expression tag |
| Leu -21 | - | expression tag |
| Ala -20 | - | expression tag |
| Phe -19 | - | expression tag |
| Phe -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ser -16 | - | expression tag |
| Ala -15 | - | expression tag |
| Ile -14 | - | expression tag |
| Lys -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Val -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Arg -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Ser 199 | - | expression tag |
| Arg 200 | - | expression tag |
| Gly 201 | - | expression tag |
| Gly 202 | - | expression tag |
| Leu 203 | - | expression tag |
| Glu 204 | - | expression tag |
| Val 205 | - | expression tag |
| Leu 206 | - | expression tag |
| Phe 207 | - | expression tag |
| Gln 208 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 105556.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 716.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 106936.8 |
