4P0N
Crystal structure of PDE10a with a novel Imidazo[4,5-b]pyridine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 338 | 38889.6 | 2 | UniProt (Q9Y233) | Homo sapiens (Human) | |
| 2 | C, K (A, B) | N-[trans-3-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl]-1,3-benzothiazol-2-amine | non-polymer | 351.4 | 2 | Chemie (1IS) | |||
| 3 | D, J (A, B) | N-[cis-3-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl]-1,3-benzothiazol-2-amine | non-polymer | 351.4 | 2 | Chemie (1IR) | |||
| 4 | E, F, L, M (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | G, H, N, O, P... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 6 | I, R (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | S, T (A, B) | water | water | 18.0 | 553 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77779.2 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2427.9 | |
| All* | Total formula weight | 80207.1 |
