Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
A | 0007165 | biological_process | signal transduction |
A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
B | 0007165 | biological_process | signal transduction |
B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | binding site for residue 1IS A 801 |
Chain | Residue |
A | ILE682 |
A | HOH977 |
A | HOH1083 |
A | HOH1117 |
A | HOH1157 |
A | TYR683 |
A | PRO702 |
A | MET703 |
A | VAL712 |
A | GLY715 |
A | GLN716 |
A | PHE719 |
A | 1IR802 |
site_id | AC2 |
Number of Residues | 11 |
Details | binding site for residue 1IR A 802 |
Chain | Residue |
A | ILE682 |
A | TYR683 |
A | PRO702 |
A | MET703 |
A | VAL712 |
A | GLY715 |
A | GLN716 |
A | PHE719 |
A | 1IS801 |
A | HOH977 |
A | HOH1117 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue ZN A 803 |
Chain | Residue |
A | HIS519 |
A | HIS553 |
A | ASP554 |
A | ASP664 |
A | ZN804 |
A | HOH1119 |
A | HOH1121 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue ZN A 804 |
Chain | Residue |
A | ASP554 |
A | ZN803 |
A | HOH958 |
A | HOH987 |
A | HOH1016 |
A | HOH1120 |
A | HOH1121 |
site_id | AC5 |
Number of Residues | 8 |
Details | binding site for residue SO4 A 805 |
Chain | Residue |
A | LYS497 |
A | GLY597 |
A | HIS598 |
A | ASN599 |
A | SER602 |
A | HOH981 |
A | HOH1040 |
A | HOH1059 |
site_id | AC6 |
Number of Residues | 8 |
Details | binding site for residue SO4 A 806 |
Chain | Residue |
A | PHE472 |
A | GLU473 |
A | ASN474 |
A | ARG510 |
A | ARG558 |
A | HIS570 |
A | HOH908 |
A | HOH921 |
site_id | AC7 |
Number of Residues | 9 |
Details | binding site for residue GOL A 807 |
Chain | Residue |
A | ARG457 |
A | GLU461 |
A | HIS466 |
A | PHE467 |
A | ASP468 |
A | LEU671 |
A | LYS695 |
A | HOH905 |
A | HOH912 |
site_id | AC8 |
Number of Residues | 11 |
Details | binding site for residue 1IR B 801 |
Chain | Residue |
B | ILE682 |
B | TYR683 |
B | PRO702 |
B | MET703 |
B | VAL712 |
B | GLY715 |
B | GLN716 |
B | PHE719 |
B | 1IS802 |
B | HOH1015 |
B | HOH1051 |
site_id | AC9 |
Number of Residues | 11 |
Details | binding site for residue 1IS B 802 |
Chain | Residue |
B | ILE682 |
B | TYR683 |
B | PRO702 |
B | MET703 |
B | VAL712 |
B | GLY715 |
B | GLN716 |
B | PHE719 |
B | 1IR801 |
B | HOH1036 |
B | HOH1051 |
site_id | AD1 |
Number of Residues | 7 |
Details | binding site for residue ZN B 803 |
Chain | Residue |
B | HIS519 |
B | HIS553 |
B | ASP554 |
B | ASP664 |
B | ZN804 |
B | HOH948 |
B | HOH1049 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue ZN B 804 |
Chain | Residue |
B | ASP554 |
B | ZN803 |
B | HOH955 |
B | HOH958 |
B | HOH988 |
B | HOH1049 |
B | HOH1133 |
site_id | AD3 |
Number of Residues | 7 |
Details | binding site for residue SO4 B 805 |
Chain | Residue |
B | LYS497 |
B | LEU595 |
B | GLY597 |
B | HIS598 |
B | ASN599 |
B | HOH1070 |
B | HOH1090 |
site_id | AD4 |
Number of Residues | 7 |
Details | binding site for residue SO4 B 806 |
Chain | Residue |
A | LEU537 |
A | LEU646 |
A | ASN647 |
B | LEU537 |
B | LEU646 |
B | ASN647 |
B | ARG652 |
site_id | AD5 |
Number of Residues | 8 |
Details | binding site for residue SO4 B 807 |
Chain | Residue |
B | PHE472 |
B | GLU473 |
B | ASN474 |
B | ARG510 |
B | ARG558 |
B | HIS570 |
B | HOH903 |
B | HOH924 |
site_id | AD6 |
Number of Residues | 9 |
Details | binding site for residue SO4 B 808 |
Chain | Residue |
B | SER605 |
B | SER605 |
B | SER605 |
B | SER606 |
B | SER606 |
B | SER606 |
B | HOH921 |
B | HOH921 |
B | HOH921 |
site_id | AD7 |
Number of Residues | 7 |
Details | binding site for residue GOL B 809 |
Chain | Residue |
B | ARG457 |
B | GLU461 |
B | HIS466 |
B | PHE467 |
B | ASP468 |
B | LYS695 |
B | HOH920 |
Functional Information from PROSITE/UniProt
site_id | PS00126 |
Number of Residues | 12 |
Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY |
Chain | Residue | Details |
A | HIS553-TYR564 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | CYS552 | |
A | GLU596 | |
A | GLY630 | |
A | GLN649 | |
B | CYS552 | |
B | GLU596 | |
B | GLY630 | |
B | GLN649 | |