Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue 1IS A 801 |
| Chain | Residue |
| A | ILE682 |
| A | HOH977 |
| A | HOH1083 |
| A | HOH1117 |
| A | HOH1157 |
| A | TYR683 |
| A | PRO702 |
| A | MET703 |
| A | VAL712 |
| A | GLY715 |
| A | GLN716 |
| A | PHE719 |
| A | 1IR802 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue 1IR A 802 |
| Chain | Residue |
| A | ILE682 |
| A | TYR683 |
| A | PRO702 |
| A | MET703 |
| A | VAL712 |
| A | GLY715 |
| A | GLN716 |
| A | PHE719 |
| A | 1IS801 |
| A | HOH977 |
| A | HOH1117 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 803 |
| Chain | Residue |
| A | HIS519 |
| A | HIS553 |
| A | ASP554 |
| A | ASP664 |
| A | ZN804 |
| A | HOH1119 |
| A | HOH1121 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 804 |
| Chain | Residue |
| A | ASP554 |
| A | ZN803 |
| A | HOH958 |
| A | HOH987 |
| A | HOH1016 |
| A | HOH1120 |
| A | HOH1121 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 805 |
| Chain | Residue |
| A | LYS497 |
| A | GLY597 |
| A | HIS598 |
| A | ASN599 |
| A | SER602 |
| A | HOH981 |
| A | HOH1040 |
| A | HOH1059 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 806 |
| Chain | Residue |
| A | PHE472 |
| A | GLU473 |
| A | ASN474 |
| A | ARG510 |
| A | ARG558 |
| A | HIS570 |
| A | HOH908 |
| A | HOH921 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 807 |
| Chain | Residue |
| A | ARG457 |
| A | GLU461 |
| A | HIS466 |
| A | PHE467 |
| A | ASP468 |
| A | LEU671 |
| A | LYS695 |
| A | HOH905 |
| A | HOH912 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue 1IR B 801 |
| Chain | Residue |
| B | ILE682 |
| B | TYR683 |
| B | PRO702 |
| B | MET703 |
| B | VAL712 |
| B | GLY715 |
| B | GLN716 |
| B | PHE719 |
| B | 1IS802 |
| B | HOH1015 |
| B | HOH1051 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | binding site for residue 1IS B 802 |
| Chain | Residue |
| B | ILE682 |
| B | TYR683 |
| B | PRO702 |
| B | MET703 |
| B | VAL712 |
| B | GLY715 |
| B | GLN716 |
| B | PHE719 |
| B | 1IR801 |
| B | HOH1036 |
| B | HOH1051 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue ZN B 803 |
| Chain | Residue |
| B | HIS519 |
| B | HIS553 |
| B | ASP554 |
| B | ASP664 |
| B | ZN804 |
| B | HOH948 |
| B | HOH1049 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue ZN B 804 |
| Chain | Residue |
| B | ASP554 |
| B | ZN803 |
| B | HOH955 |
| B | HOH958 |
| B | HOH988 |
| B | HOH1049 |
| B | HOH1133 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 805 |
| Chain | Residue |
| B | LYS497 |
| B | LEU595 |
| B | GLY597 |
| B | HIS598 |
| B | ASN599 |
| B | HOH1070 |
| B | HOH1090 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 806 |
| Chain | Residue |
| A | LEU537 |
| A | LEU646 |
| A | ASN647 |
| B | LEU537 |
| B | LEU646 |
| B | ASN647 |
| B | ARG652 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 807 |
| Chain | Residue |
| B | PHE472 |
| B | GLU473 |
| B | ASN474 |
| B | ARG510 |
| B | ARG558 |
| B | HIS570 |
| B | HOH903 |
| B | HOH924 |
| site_id | AD6 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 808 |
| Chain | Residue |
| B | SER605 |
| B | SER605 |
| B | SER605 |
| B | SER606 |
| B | SER606 |
| B | SER606 |
| B | HOH921 |
| B | HOH921 |
| B | HOH921 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 809 |
| Chain | Residue |
| B | ARG457 |
| B | GLU461 |
| B | HIS466 |
| B | PHE467 |
| B | ASP468 |
| B | LYS695 |
| B | HOH920 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY |
| Chain | Residue | Details |
| A | HIS553-TYR564 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17389385","evidenceCode":"ECO:0000269"}]} |
