4OTF
Crystal structure of the kinase domain of Bruton's Tyrosine kinase with GDC0834
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase BTK | polymer | 271 | 31732.4 | 1 | UniProt (Q06187) Pfam (PF07714) | Homo sapiens (human) | Agammaglobulinemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK, Bruton tyrosine kinase |
| 2 | B, C, D (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | E (A) | N-{3-[6-({4-[(2R)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl }-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | non-polymer | 596.7 | 1 | Chemie (2VL) | |||
| 4 | F (A) | water | water | 18.0 | 182 | Chemie (HOH) |
Sequence modifications
A: 393 - 657 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Met 392 | - | initiating methionine |
| Asn 658 | - | expression tag |
| Leu 659 | - | expression tag |
| Tyr 660 | - | expression tag |
| Gly 661 | - | expression tag |
| Asn 662 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31732.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 884.9 | |
| All* | Total formula weight | 32617.4 |
