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4OTF

Crystal structure of the kinase domain of Bruton's Tyrosine kinase with GDC0834

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 701
ChainResidue
ALYS466
AARG487
AARG490
ALYS595
AHOH831

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 702
ChainResidue
AARG490
AHIS491
ALYS637

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 703
ChainResidue
ALYS595
ATYR617
APRO619
AHIS620
AHOH823
AHOH911
ASER592

site_idAC4
Number of Residues21
DetailsBINDING SITE FOR RESIDUE 2VL A 704
ChainResidue
ALYS406
AGLU407
ALEU408
ATHR410
APHE413
AVAL416
AALA428
ALYS430
ATHR474
AGLU475
ATYR476
AMET477
AGLY480
AASN526
ALEU528
AASP539
ATYR551
AHOH810
AHOH884
AHOH889
AHOH895

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues23
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGQFGVVKyGkwrgqyd...........VAIK
ChainResidueDetails
ALEU408-LYS430

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCLV
ChainResidueDetails
APHE517-VAL529

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
AASP521

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU408
ALYS430

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:20052711, ECO:0007744|PDB:3K54, ECO:0007744|PDB:3OCT
ChainResidueDetails
ATHR474

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:21280133, ECO:0007744|PDB:3PIY
ChainResidueDetails
ALEU542

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by LYN and SYK => ECO:0000269|PubMed:8630736, ECO:0000269|PubMed:9012831
ChainResidueDetails
ATYR551

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER604

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:15375214
ChainResidueDetails
ATYR617

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:15375214
ChainResidueDetails
ASER623

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PDB entries from 2024-07-24

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