4OR5
Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, F) | Cyclin-dependent kinase 9 | polymer | 326 | 37544.6 | 2 | UniProt (P50750) Pfam (PF00069) | Homo sapiens (human) | C-2K, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, Tat-associated kinase complex catalytic subunit |
| 2 | B, F (B, G) | Cyclin-T1 | polymer | 266 | 30877.3 | 2 | UniProt (O60563) Pfam (PF00134) Pfam (PF21797) | Homo sapiens (human) | CycT1, Cyclin-T |
| 3 | C, G (C, H) | Protein Tat | polymer | 48 | 5428.4 | 2 | UniProt (P04608) Pfam (PF00539) | HIV-1 | Transactivating regulatory protein |
| 4 | D, H (E, J) | AF4/FMR2 family member 4 | polymer | 43 | 4887.5 | 2 | UniProt (Q9UHB7) | Homo sapiens (human) | ALL1-fused gene from chromosome 5q31 protein, Protein AF-5q31, Major CDK9 elongation factor-associated protein |
| 5 | AA, BA, FA, I, J... (G, J, A, B, E...) | YTTRIUM (III) ION | non-polymer | 88.9 | 16 | Chemie (YT3) | |||
| 6 | CA, L, P, Y (G, A, B, F) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 7 | DA, EA, Q, R (H, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 8 | GA, HA, IA, JA, KA... (A, B, C, E, F...) | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence modifications
E, J: 32 - 69 (UniProt: Q9UHB7)
| PDB | External Database | Details |
|---|---|---|
| Glu 27 | - | expression tag |
| Gln 28 | - | expression tag |
| Ile 29 | - | expression tag |
| Gly 30 | - | expression tag |
| Gly 31 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 157475.6 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 2068.4 | |
| All* | Total formula weight | 159543.9 |
