4OR5

Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F	Cyclin-dependent kinase 9	polymer	326	37544.6	2	UniProt (P50750) Pfam (PF00069) In PDB	Homo sapiens (human)	C-2K, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, Tat-associated kinase complex catalytic subunit
2	B, G	Cyclin-T1	polymer	266	30877.3	2	UniProt (O60563) Pfam (PF00134) Pfam (PF21797) In PDB	Homo sapiens (human)	CycT1, Cyclin-T
3	C, H	Protein Tat	polymer	48	5428.4	2	UniProt (P04608) Pfam (PF00539) In PDB	HIV-1	Transactivating regulatory protein
4	E, J	AF4/FMR2 family member 4	polymer	43	4887.5	2	UniProt (Q9UHB7) In PDB	Homo sapiens (human)	ALL1-fused gene from chromosome 5q31 protein, Protein AF-5q31, Major CDK9 elongation factor-associated protein
5	G, J, A, B, E...	YTTRIUM (III) ION	non-polymer		88.9	16	Chemie (YT3)
6	G, A, B, F	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
7	H, C	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
8		water	water		18.0	100	Chemie (HOH)

Sequence modifications

E, J: 32 - 69 (UniProt: Q9UHB7)

PDB	External Database	Details
Glu 27	-	EXPRESSION TAG
Gln 28	-	EXPRESSION TAG
Ile 29	-	EXPRESSION TAG
Gly 30	-	EXPRESSION TAG
Gly 31	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	157475.6
Non-Polymers*	Number of molecules	24
	Total formula weight	2068.4
All*	Total formula weight	159543.9

*Water molecules are not included.