4OQE

Crystal structure of the tylM1 N,N-dimethyltransferase in complex with SAH and TDP-Fuc3NMe

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase	polymer	263	28537.9	2	UniProt (P95748) Pfam (PF13649)	Streptomyces fradiae	Tylosin biosynthesis protein M1
2	C, E (A, B)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
3	D, F (A, B)	dTDP-3-N-methylamino-3,6-dideoxygalactose	non-polymer		561.4	2	Chemie (MMF)
4	G, H (A, B)	water	water		18.0	212	Chemie (HOH)

Sequence modifications

A, B: 1 - 255 (UniProt: P95748)

PDB	External Database	Details
Leu 256	-	expression tag
Glu 257	-	expression tag
His 258	-	expression tag
His 259	-	expression tag
His 260	-	expression tag
His 261	-	expression tag
His 262	-	expression tag
His 263	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	57075.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1891.6
All*	Total formula weight	58967.3

*Water molecules are not included.