4OQE
Crystal structure of the tylM1 N,N-dimethyltransferase in complex with SAH and TDP-Fuc3NMe
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
A | 0009058 | biological_process | biosynthetic process |
A | 0017000 | biological_process | antibiotic biosynthetic process |
A | 0032259 | biological_process | methylation |
A | 0042803 | molecular_function | protein homodimerization activity |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
B | 0009058 | biological_process | biosynthetic process |
B | 0017000 | biological_process | antibiotic biosynthetic process |
B | 0032259 | biological_process | methylation |
B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE SAH A 300 |
Chain | Residue |
A | TYR14 |
A | ASP101 |
A | MET102 |
A | MET117 |
A | PHE118 |
A | SER120 |
A | MMF301 |
A | HOH409 |
A | HOH411 |
A | HOH428 |
A | TYR22 |
A | TYR33 |
A | ALA58 |
A | GLY60 |
A | HIS64 |
A | GLU79 |
A | LEU80 |
A | SER81 |
site_id | AC2 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE MMF A 301 |
Chain | Residue |
A | TYR14 |
A | LYS29 |
A | PHE118 |
A | TRP152 |
A | TRP153 |
A | ASN157 |
A | PHE158 |
A | THR159 |
A | TYR162 |
A | ALA164 |
A | ARG177 |
A | SER179 |
A | SER181 |
A | ILE190 |
A | HIS210 |
A | ILE212 |
A | ARG241 |
A | SAH300 |
A | HOH479 |
site_id | AC3 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE SAH B 300 |
Chain | Residue |
B | TYR14 |
B | TYR22 |
B | TYR33 |
B | ALA58 |
B | CYS59 |
B | GLY60 |
B | HIS64 |
B | GLU79 |
B | LEU80 |
B | SER81 |
B | MET84 |
B | ASP101 |
B | MET102 |
B | MET117 |
B | PHE118 |
B | SER120 |
B | MMF301 |
B | HOH427 |
B | HOH465 |
site_id | AC4 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE MMF B 301 |
Chain | Residue |
B | TYR14 |
B | LYS29 |
B | PHE118 |
B | HIS123 |
B | TRP152 |
B | TRP153 |
B | ASN157 |
B | PHE158 |
B | THR159 |
B | TYR162 |
B | ALA164 |
B | ARG177 |
B | SER179 |
B | SER181 |
B | HIS210 |
B | ARG241 |
B | SAH300 |
B | HOH444 |
B | HOH455 |
B | HOH459 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21142177 |
Chain | Residue | Details |
A | TYR14 | |
B | ALA58 | |
B | GLU79 | |
B | MET117 | |
A | TYR22 | |
A | TYR33 | |
A | ALA58 | |
A | GLU79 | |
A | MET117 | |
B | TYR14 | |
B | TYR22 | |
B | TYR33 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP101 | |
B | ASP101 |