4OQ6
Crystal Structure of Human MCL-1 Bound to Inhibitor 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 157 | 17882.4 | 2 | UniProt (Q07820) Pfam (PF00452) In PDB | Homo sapiens (human) | Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT |
| 2 | A, B | 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid | non-polymer | 256.3 | 2 | Chemie (2UV) | |||
| 3 | water | water | 18.0 | 145 | Chemie (HOH) |
Sequence modifications
A, B: 174 - 326 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 170 | - | expression tag |
| Ser 171 | - | expression tag |
| Met 172 | - | expression tag |
| Asp 173 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35764.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 512.6 | |
| All* | Total formula weight | 36277.4 |
