4OQ6
Crystal Structure of Human MCL-1 Bound to Inhibitor 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid
Experimental procedure
Experimental method | SINGLE WAVELENGTH |
Source type | SYNCHROTRON |
Source details | APS BEAMLINE 17-ID |
Synchrotron site | APS |
Beamline | 17-ID |
Temperature [K] | 100 |
Detector technology | PIXEL |
Detector | DECTRIS PILATUS 6M |
Wavelength(s) | 1.0000 |
Spacegroup name | C 1 2 1 |
Unit cell lengths | 106.500, 61.830, 47.490 |
Unit cell angles | 90.00, 116.42, 90.00 |
Refinement procedure
Resolution | 51.880 - 1.810 |
R-factor | 0.2031 |
Rwork | 0.202 |
R-free | 0.23020 |
Structure solution method | MOLECULAR REPLACEMENT |
Phasing software | PHASER |
Refinement software | BUSTER-TNT (2.5.1) |
Data quality characteristics
Overall | Outer shell | |
Low resolution limit [Å] | 51.880 | |
High resolution limit [Å] | 1.810 | 1.810 |
Number of reflections | 25174 | |
Completeness [%] | 99.4 |
Crystallization Conditions
crystal ID | method | pH | temperature | details |
1 | VAPOR DIFFUSION, SITTING DROP | VAPOR DIFFUSION, SITTING DROP |