4OQ3
Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | E3 ubiquitin-protein ligase Mdm2 | polymer | 96 | 11172.0 | 4 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2 |
| 2 | E, F, G, H (A, B, C, D) | 1-(5-chloro-2-methylphenyl)-5-(3-chlorophenyl)-2-(3-methylphenyl)-1H-imidazole-4-carboxylic acid | non-polymer | 437.3 | 4 | Chemie (2V8) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 194 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 17 - 111 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
| Glu 33 | Leu 33 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 44688.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1749.3 | |
| All* | Total formula weight | 46437.3 |
