4OQ3
Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0051726 | biological_process | regulation of cell cycle |
| B | 0005634 | cellular_component | nucleus |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0051726 | biological_process | regulation of cell cycle |
| C | 0005634 | cellular_component | nucleus |
| C | 0043066 | biological_process | negative regulation of apoptotic process |
| C | 0051726 | biological_process | regulation of cell cycle |
| D | 0005634 | cellular_component | nucleus |
| D | 0043066 | biological_process | negative regulation of apoptotic process |
| D | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 2V8 A 201 |
| Chain | Residue |
| A | LEU54 |
| A | HIS96 |
| A | ILE99 |
| A | HOH329 |
| A | HOH339 |
| C | TYR76 |
| C | PRO89 |
| C | HOH302 |
| A | GLY58 |
| A | ILE61 |
| A | MET62 |
| A | TYR67 |
| A | GLN72 |
| A | PHE91 |
| A | VAL93 |
| A | LYS94 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 2V8 B 201 |
| Chain | Residue |
| B | LEU54 |
| B | GLY58 |
| B | ILE61 |
| B | TYR67 |
| B | GLN72 |
| B | PHE91 |
| B | VAL93 |
| B | LYS94 |
| B | HIS96 |
| B | ILE99 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 2V8 C 201 |
| Chain | Residue |
| A | TYR76 |
| A | PRO89 |
| A | HOH304 |
| A | HOH305 |
| C | LEU54 |
| C | GLY58 |
| C | ILE61 |
| C | MET62 |
| C | GLN72 |
| C | PHE91 |
| C | VAL93 |
| C | LYS94 |
| C | HIS96 |
| C | ILE99 |
| C | HOH333 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 2V8 D 201 |
| Chain | Residue |
| D | LEU54 |
| D | GLY58 |
| D | ILE61 |
| D | MET62 |
| D | TYR67 |
| D | GLN72 |
| D | PHE91 |
| D | VAL93 |
| D | LYS94 |
| D | HIS96 |
