4ONT

Ternary host recognition complex of complement factor H, C3d, and sialic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E (F, D, E)	Complement factor H	polymer	129	14773.8	3	UniProt (P08603) Pfam (PF00084)	Homo sapiens (human)	H factor 1
2	B, D, F (A, B, C)	Complement C3d fragment	polymer	317	35444.4	3	UniProt (P01024) Pfam (PF07678)	Homo sapiens (human)	C3d
3	G, H, I (G, H, I)	N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose	branched		633.6	3	In PDB GlyTouCan (G91237TK)
4	J, K, L, M, N... (A, B, E, C)	GLYCEROL	non-polymer		92.1	7	Chemie (GOL)
5	Q, R, S, T, U... (F, A, D, B, E...)	water	water		18.0	489	Chemie (HOH)

Sequence modifications

F, D, E: 1107 - 1231 (UniProt: P08603)

PDB	External Database	Details
Glu 1103	-	expression tag
Ala 1104	-	expression tag
Glu 1105	-	expression tag
Phe 1106	-	expression tag

A, B, C: 3 - 310 (UniProt: P01024)

PDB	External Database	Details
Gly -6	-	expression tag
Pro -5	-	expression tag
Leu -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Pro -1	-	expression tag
Glu 0	-	expression tag
Phe 1	-	expression tag
Arg 2	-	expression tag
Ala 17	Cys 1010	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	150654.7
Branched	Number of molecules	3
	Total formula weight	1900.7
Non-Polymers*	Number of molecules	7
	Total formula weight	644.7
All*	Total formula weight	153200.0

*Water molecules are not included.