4OMO
Crystal structure of the c-Src tyrosine kinase SH3 domain mutant Q128E
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase Src | polymer | 61 | 6906.5 | 2 | UniProt (P00523) Pfam (PF00018) | Gallus gallus (bantam chickens) | Proto-oncogene c-Src, pp60c-src, p60-Src |
| 2 | C, E (A, B) | NICKEL (II) ION | non-polymer | 58.7 | 2 | Chemie (NI) | |||
| 3 | D (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 155 | Chemie (HOH) |
Sequence modifications
A, B: 85 - 141 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 81 | - | expression tag |
| Ser 82 | - | expression tag |
| His 83 | - | expression tag |
| Met 84 | - | expression tag |
| Glu 128 | Gln 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 13813.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 355.7 | |
| All* | Total formula weight | 14168.7 |
