4OMN
Crystal structure of the intertwined dimer of the c-Src tyrosine kinase SH3 domain mutant Q128E
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proto-oncogene tyrosine-protein kinase Src | polymer | 77 | 8680.5 | 1 | UniProt (P00523) Pfam (PF00018) | Gallus gallus (bantam chickens) | Proto-oncogene c-Src, pp60c-src, p60-Src |
| 2 | B (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 3 | C, D (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 4 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | G (A) | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A: 85 - 140 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Met 64 | - | initiating methionine |
| Gly 65 | - | expression tag |
| Ser 66 | - | expression tag |
| Ser 67 | - | expression tag |
| His 68 | - | expression tag |
| His 69 | - | expression tag |
| His 70 | - | expression tag |
| His 71 | - | expression tag |
| His 72 | - | expression tag |
| His 73 | - | expression tag |
| Ser 74 | - | expression tag |
| Ser 75 | - | expression tag |
| Gly 76 | - | expression tag |
| Leu 77 | - | expression tag |
| Val 78 | - | expression tag |
| Pro 79 | - | expression tag |
| Arg 80 | - | expression tag |
| Gly 81 | - | expression tag |
| Ser 82 | - | expression tag |
| His 83 | - | expression tag |
| Met 84 | - | expression tag |
| Glu 128 | Gln 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 8680.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 550.6 | |
| All* | Total formula weight | 9231.1 |
