4OLI

The pseudokinase/kinase protein from JAK-family member TYK2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Non-receptor tyrosine-protein kinase TYK2	polymer	645	73304.2	1	UniProt (P29597) Pfam (PF07714)	Homo sapiens (human)
2	B, C (A)	2-chloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide	non-polymer		315.8	2	Chemie (2TT)
3	D (A)	water	water		18.0	8	Chemie (HOH)

Sequence modifications

A: 566 - 1187 (UniProt: P29597)

PDB	External Database	Details
Met 543	-	expression tag
Ser 544	-	expression tag
Tyr 545	-	expression tag
Tyr 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag
His 550	-	expression tag
His 551	-	expression tag
His 552	-	expression tag
Asp 553	-	expression tag
Tyr 554	-	expression tag
Asp 555	-	expression tag
Ile 556	-	expression tag
Pro 557	-	expression tag
Thr 558	-	expression tag
Thr 559	-	expression tag
Glu 560	-	expression tag
Asn 561	-	expression tag
Leu 562	-	expression tag
Tyr 563	-	expression tag
Phe 564	-	expression tag
Gln 565	-	expression tag
Ser 1016	Ala 1016	SEE REMARK 999
Asn 1023	Asp 1023	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	73304.2
Non-Polymers*	Number of molecules	2
	Total formula weight	631.5
All*	Total formula weight	73935.7

*Water molecules are not included.