4OLI

The pseudokinase/kinase protein from JAK-family member TYK2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0016020	cellular_component	membrane
A	0035556	biological_process	intracellular signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 2TT A 1201

Chain	Residue
A	LEU595
A	GLY693
A	LEU741
A	ARG1058
A	GLY596
A	GLN597
A	VAL603
A	VAL640
A	GLU688
A	TYR689
A	VAL690
A	GLU691

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site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 2TT A 1202

Chain	Residue
A	LEU903
A	GLU905
A	VAL911
A	GLU979
A	TYR980
A	VAL981
A	PRO982
A	GLY984
A	ASN1028
A	LEU1030
A	GLY1040
A	ASP1041

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	28
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGHFGKVSlYcydptndgtgem......VAVK

Chain	Residue	Details
A	LEU903-LYS930

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASN1023

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LYS930
A	LEU903

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9R117

Chain	Residue	Details
A	TYR604

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	SER884

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:20478313, ECO:0000269|PubMed:8702790

Chain	Residue	Details
A	TYR1054

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:8702790

Chain	Residue	Details
A	TYR1055

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