4OKB

Crystal structure of W741L-AR-LBD bound with co-regulator peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Androgen receptor	polymer	250	29015.0	1	UniProt (P10275) Pfam (PF00104) In PDB	Homo sapiens (human)	Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
2	B	Protein BUD31 homolog	polymer	15	2017.4	1	UniProt (P41223) In PDB	Homo sapiens	Protein EDG-2, Protein G10 homolog
3	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	A	R-BICALUTAMIDE	non-polymer		430.4	1	Chemie (198)
5		water	water		18.0	20	Chemie (HOH)

Sequence modifications

A: 670 - 919 (UniProt: P10275)

PDB	External Database	Details
Leu 741	Trp 741	engineered mutation
Ala 760	Arg 760	engineered mutation

B: -2 - 12 (UniProt: P41223)

PDB	External Database	Details
Tyr 12	Ile 70	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	31032.4
Non-Polymers*	Number of molecules	2
	Total formula weight	526.4
All*	Total formula weight	31558.9

*Water molecules are not included.