4O76
Crystal structure of the first bromodomain of human BRD4 in complex with TG101209
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 4 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (human) | Protein HUNK1 |
2 | A, B, C, D | N-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | non-polymer | 509.7 | 4 | Chemie (1M3) | |||
3 | A, B, D | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
4 | water | water | 18.0 | 427 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 44 - 168 (UniProt: O60885)
PDB | External Database | Details |
---|---|---|
Ser 42 | - | expression tag |
Met 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 60397.5 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2286.9 | |
All* | Total formula weight | 62684.5 |