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4O76

Crystal structure of the first bromodomain of human BRD4 in complex with TG101209

Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 1M3 A 201
ChainResidue
ATRP81
BMET149
APRO82
APHE83
ALEU92
ALEU94
AASN140
AHOH315
BASP145
BLEU148

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 202
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 1M3 B 201
ChainResidue
ATRP81
AASP145
ALEU148
AMET149
AHOH367
BPRO82
BLEU92
BASN140
BHOH367

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO B 202
ChainResidue
BLYS111
BLYS112
BGLU115
BHOH310
DILE138
DTYR139
DASN140
DLYS141

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 203
ChainResidue
BILE100
BILE101
BLYS102
BTHR103
BASN135

site_idAC6
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 1M3 C 201
ChainResidue
CTRP81
CPRO82
CVAL87
CLEU92
CLEU94
CASN140
DASP145
DLEU148
DMET149
D1M3201

site_idAC7
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 1M3 D 201
ChainResidue
CPHE79
CTRP81
CASP145
CLEU148
C1M3201
DTRP81
DPRO82
DPHE83
DLEU92
DASN140
DHOH323

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO D 202
ChainResidue
DILE100
DILE101
DLYS102
DTHR103
DASN135

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues424
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues4
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

248942

PDB entries from 2026-02-11

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