4O1U
Crystal structure of human thymidylate synthase mutant Y202C
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Thymidylate synthase | polymer | 325 | 37398.9 | 2 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (human) | TS, TSase |
2 | A, B | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
4 | A, B | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
5 | water | water | 18.0 | 186 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 313 (UniProt: P04818)
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Arg -10 | - | expression tag |
Gly -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Cme 202 | Tyr 202 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 74797.9 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 931.0 | |
All* | Total formula weight | 75728.9 |