4NYW
Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CREB-binding protein | polymer | 119 | 14223.3 | 1 | UniProt (Q92793) Pfam (PF00439) | Homo sapiens (human) | |
| 2 | B (A) | THIOCYANATE ION | non-polymer | 58.1 | 1 | Chemie (SCN) | |||
| 3 | C (A) | (3R)-N-[3-(3,4-dihydroquinolin-1(2H)-yl)propyl]-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxamide | non-polymer | 378.5 | 1 | Chemie (2O3) | |||
| 4 | D, E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | F (A) | water | water | 18.0 | 186 | Chemie (HOH) |
Sequence modifications
A: 1081 - 1197 (UniProt: Q92793)
| PDB | External Database | Details |
|---|---|---|
| Ser 1079 | - | expression tag |
| Met 1080 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 14223.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 560.7 | |
| All* | Total formula weight | 14784.0 |
