4NYW

Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SCN A 1201

Chain	Residue
A	TRP1151
A	VAL1154
A	THR1171
A	LYS1176
A	HOH1422

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 2O3 A 1202

Chain	Residue
A	ARG1173
A	VAL1174
A	EDO1204
A	HOH1303
A	HOH1317
A	HOH1367
A	HOH1396
A	PRO1110
A	VAL1115
A	LEU1120
A	ASN1168

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO A 1203

Chain	Residue
A	PRO1087
A	GLU1088
A	ARG1091
A	LEU1142
A	ASP1143
A	GLY1145
A	ARG1169
A	ASP1190
A	HOH1309
A	HOH1393

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 1204

Chain	Residue
A	PRO1106
A	LEU1109
A	SER1179
A	2O31202
A	HOH1308
A	HOH1323
A	HOH1338
A	HOH1362

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY

Chain	Residue	Details
A	SER1108-TYR1167

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	107
Details	Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	46
Details	Region: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"24361270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Region: {"description":"Interaction with ASF1A","evidences":[{"source":"PubMed","id":"24616510","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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