4NVQ
Human G9a in Complex with Inhibitor A-366
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Histone-lysine N-methyltransferase EHMT2 | polymer | 285 | 32874.3 | 2 | UniProt (Q96KQ7) Pfam (PF05033) Pfam (PF00856) In PDB | Homo sapiens (human) | Euchromatic histone-lysine N-methyltransferase 2, HLA-B-associated transcript 8, Histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, Lysine N-methyltransferase 1C, Protein G9a |
| 2 | A, B | 5'-methoxy-6'-[3-(pyrrolidin-1-yl)propoxy]spiro[cyclobutane-1,3'-indol]-2'-amine | non-polymer | 329.4 | 2 | Chemie (2OD) | |||
| 3 | A, B | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 4 | A, B | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 5 | water | water | 18.0 | 243 | Chemie (HOH) |
Sequence modifications
A, B: 913 - 1193 (UniProt: Q96KQ7)
| PDB | External Database | Details |
|---|---|---|
| Gly 909 | - | expression tag |
| Ser 910 | - | expression tag |
| His 911 | - | expression tag |
| Met 912 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65748.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1951.0 | |
| All* | Total formula weight | 67699.5 |
