4NPW
Crystal structure of human PDE1B bound to inhibitor 19A (7,8-dimethoxy-N-[(2S)-1-(3-methyl-1H-pyrazol-5-yl)propan-2-yl]quinazolin-4-amine)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | polymer | 369 | 42134.9 | 1 | UniProt (Q01064) Pfam (PF00233) | Homo sapiens (human) | Cam-PDE 1B, 63 kDa Cam-PDE |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | 7,8-dimethoxy-N-[(2S)-1-(3-methyl-1H-pyrazol-5-yl)propan-2-yl]quinazolin-4-amine | non-polymer | 327.4 | 1 | Chemie (0NY) | |||
| 5 | E (A) | water | water | 18.0 | 249 | Chemie (HOH) |
Sequence modifications
A: 142 - 507 (UniProt: Q01064)
| PDB | External Database | Details |
|---|---|---|
| Gly 139 | - | expression tag |
| Ser 140 | - | expression tag |
| Met 141 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42134.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 417.1 | |
| All* | Total formula weight | 42552.0 |
