4NPW

Crystal structure of human PDE1B bound to inhibitor 19A (7,8-dimethoxy-N-[(2S)-1-(3-methyl-1H-pyrazol-5-yl)propan-2-yl]quinazolin-4-amine)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	HIS227
A	HIS263
A	ASP264
A	ASP370
A	HOH1112
A	HOH1116

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1002

Chain	Residue
A	HOH1113
A	HOH1114
A	HOH1115
A	ASP264
A	HOH1111
A	HOH1112

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site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 0NY A 1003

Chain	Residue
A	TYR222
A	HIS223
A	HIS373
A	LEU388
A	PHE392
A	LEU409
A	GLN421
A	PHE424
A	HOH1101
A	HOH1102
A	HOH1104

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Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDYeHtGttNsF

Chain	Residue	Details
A	HIS263-PHE274

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083

Chain	Residue	Details
A	HIS223

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1TAZ, ECO:0007744|PDB:4NPV, ECO:0007744|PDB:4NPW

Chain	Residue	Details
A	HIS227
A	HIS263
A	ASP264
A	ASP370

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q01065

Chain	Residue	Details
A	SER466

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