4NNU

Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Transcription factor A, mitochondrial	polymer	230	27067.2	2	UniProt (Q00059) Pfam (PF00505) Pfam (PF09011)	Homo sapiens (human)	mtTFA, Mitochondrial transcription factor 1, MtTF1, Transcription factor 6, TCF-6, Transcription factor 6-like 2
2	C, D (C, E)	DNA1	polymer	22	6823.4	2		Homo sapiens
3	E, F (D, F)	DNA2	polymer	22	6681.3	2		Homo sapiens
4	G, H, I, J, K... (A, B, C, E, D...)	water	water		18.0	30	Chemie (HOH)

Sequence modifications

A, B: 43 - 237 (UniProt: Q00059)

PDB	External Database	Details
Met 8	-	expression tag
Gly 9	-	expression tag
Ser 10	-	expression tag
Ser 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
Ser 18	-	expression tag
Ser 19	-	expression tag
Gly 20	-	expression tag
Leu 21	-	expression tag
Val 22	-	expression tag
Pro 23	-	expression tag
Arg 24	-	expression tag
Gly 25	-	expression tag
Ser 26	-	expression tag
His 27	-	expression tag
Met 28	-	expression tag
Ala 29	-	expression tag
Ser 30	-	expression tag
Met 31	-	expression tag
Thr 32	-	expression tag
Gly 33	-	expression tag
Gly 34	-	expression tag
Gln 35	-	expression tag
Gln 36	-	expression tag
Met 37	-	expression tag
Gly 38	-	expression tag
Arg 39	-	expression tag
Gly 40	-	expression tag
Ser 41	-	expression tag
Met 42	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	81143.8
All*	Total formula weight	81143.8

*Water molecules are not included.