4NI2
Crystal structure of the heterodimeric catalytic domain of wild-type human soluble guanylate cyclase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanylate cyclase soluble subunit alpha-3 | polymer | 197 | 21786.3 | 1 | UniProt (Q02108) Pfam (PF00211) | Homo sapiens (human) | GCS-alpha-3, GCS-alpha-1, Soluble guanylate cyclase large subunit |
| 2 | B (B) | Guanylate cyclase soluble subunit beta-1 | polymer | 209 | 23567.1 | 1 | UniProt (Q02153) Pfam (PF00211) | Homo sapiens (human) | GCS-beta-1, Guanylate cyclase soluble subunit beta-3, GCS-beta-3, Soluble guanylate cyclase small subunit |
| 3 | C, D, E, F, G... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 310 | Chemie (HOH) |
Sequence modifications
A: 468 - 662 (UniProt: Q02108)
B: 408 - 608 (UniProt: Q02153)
| PDB | External Database | Details |
|---|---|---|
| Ser 466 | - | expression tag |
| Met 467 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 407 | - | expression tag |
| Ala 609 | - | expression tag |
| Glu 610 | - | expression tag |
| Asn 611 | - | expression tag |
| Leu 612 | - | expression tag |
| Tyr 613 | - | expression tag |
| Phe 614 | - | expression tag |
| Gln 615 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 45353.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 372.4 | |
| All* | Total formula weight | 45725.7 |
