4NI2
Crystal structure of the heterodimeric catalytic domain of wild-type human soluble guanylate cyclase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| A | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| A | 0035556 | biological_process | intracellular signal transduction |
| B | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| B | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| B | 0035556 | biological_process | intracellular signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 701 |
| Chain | Residue |
| A | VAL525 |
| A | GLU526 |
| A | LEU596 |
| A | HOH810 |
| A | HOH839 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 702 |
| Chain | Residue |
| A | ALA531 |
| A | HOH812 |
| A | HOH868 |
| A | ASP486 |
| A | ILE487 |
| A | TYR510 |
| A | GLY529 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 701 |
| Chain | Residue |
| A | ILE528 |
| A | GLY529 |
| A | HOH877 |
| B | GLU473 |
| B | THR474 |
| B | MET480 |
| B | HOH837 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 702 |
| Chain | Residue |
| A | LYS590 |
| B | PHE468 |
| B | GLY484 |
| B | LEU485 |
| B | PRO486 |
| B | GLU487 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 703 |
| Chain | Residue |
| B | ILE427 |
| B | VAL428 |
| B | THR520 |
| B | GLU554 |
| B | HOH828 |
| B | HOH896 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 704 |
| Chain | Residue |
| B | VAL428 |
| B | GLY429 |
| B | HOH812 |
Functional Information from PROSITE/UniProt
| site_id | PS00452 |
| Number of Residues | 24 |
| Details | GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVV.GvkmprYcLFGNNVTlankfE |
| Chain | Residue | Details |
| A | GLY585-GLU608 | |
| B | GLY531-GLU554 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 260 |
| Details | Domain: {"description":"Guanylate cyclase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"7D9U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"6JT2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HBH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
