4NHH

Structure of 2G12 IgG Dimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, G, I, M... (L, K, G, F, Q...)	2G12 IgG dimer light chain	polymer	213	23233.9	6		Homo sapiens (human)
2	B, D, H, J, N... (H, M, E, I, O...)	Hepatitis B virus receptor binding protein	polymer	229	24248.4	6	UniProt (Q6PYX1) Pfam (PF07654)	Homo sapiens (human)
3	E, F, K, L, Q... (A, B, C, D, J...)	2G12 IgG dimer heavy chain	polymer	211	23947.1	6	Pfam (PF07654) UniProt (by SIFTS) (Q6PYX1)	Homo sapiens (human)

Sequence modifications

H, M, E, I, O, R: 1 - 229 (UniProt: Q6PYX1)

PDB	External Database	Details
Glu 1	Ser 140	conflict
Gln 3	Phe 142	conflict
Val 5	-	expression tag
Glu 6	-	expression tag
Ser 7	-	expression tag
Gly 8	-	expression tag
Gly 9	-	expression tag
Gly 10	Phe 144	conflict
Leu 11	Pro 145	conflict
Val 12	Pro 146	conflict
Ala 14	Pro 148	conflict
Gly 15	Lys 149	conflict
Gly 16	Asp 150	conflict
Ser 17	Thr 151	conflict
Ile 19	Met 153	conflict
Leu 20	Ile 154	conflict
-	Arg 156	deletion
-	Thr 157	deletion
-	Pro 158	deletion
-	Glu 159	deletion
-	Val 160	deletion
-	Thr 161	deletion
Gly 23	Val 163	conflict
Ser 25	-	expression tag
Asn 26	-	expression tag
Phe 27	Val 165	conflict
Arg 28	Asp 166	conflict
Ile 29	Val 167	conflict
Ala 31	-	expression tag
-	Glu 170	deletion
-	Asp 171	deletion
-	Pro 172	deletion
-	Glu 173	deletion
-	Val 174	deletion
Thr 33	Lys 175	conflict
Met 34	Phe 176	conflict
Val 37	-	expression tag
Arg 38	-	expression tag
Arg 39	Tyr 179	conflict
Pro 41	-	expression tag
Gly 42	-	expression tag
Gly 43	Asp 181	conflict
Leu 45	Val 183	conflict
Trp 47	-	expression tag
-	His 186	deletion
-	Asn 187	deletion
-	Lys 189	deletion
-	Thr 190	deletion
-	Lys 191	deletion
-	Pro 192	deletion
-	Arg 193	deletion
-	Glu 194	deletion
Ser 50	Glu 195	conflict
Ile 51	Gln 196	conflict
Ser 52	Tyr 197	conflict
Ser 53	Asn 198	conflict
Asp 58	-	expression tag
Tyr 59	-	expression tag
Ala 60	-	expression tag
Asp 61	-	expression tag
Ala 62	-	expression tag
Lys 64	Val 204	conflict
Gly 65	Ser 205	conflict
Arg 66	Val 206	conflict
Phe 67	Leu 207	conflict
Ser 70	-	expression tag
Arg 71	-	expression tag
Asp 72	-	expression tag
Asp 73	-	expression tag
-	His 211	deletion
Glu 75	Gln 212	conflict
Phe 77	-	expression tag
Val 78	-	expression tag
Tyr 79	Trp 214	conflict
Gln 81	-	expression tag
Met 82	Asn 216	conflict
His 83	Gly 217	conflict
Arg 85	-	expression tag
Val 86	-	expression tag
Asp 88	-	expression tag
Thr 89	-	expression tag
Ala 90	-	expression tag
Ile 91	-	expression tag
Tyr 93	Lys 221	conflict
Ala 95	-	expression tag
Arg 96	-	expression tag
Gly 98	Val 224	conflict
-	Asn 226	deletion
Asp 100	Lys 227	conflict
Arg 101	Ala 228	conflict
Asp 103	Pro 230	conflict
Trp 105	-	expression tag
Gly 106	-	expression tag
Gly 108	-	expression tag
Thr 109	Ile 233	conflict
Val 110	Glu 234	conflict
Val 111	Lys 235	conflict
Val 113	Ile 237	conflict
Pro 115	Lys 239	conflict
Ser 117	-	expression tag
Thr 118	-	expression tag
-	Gln 243	deletion
-	Pro 244	deletion
-	Arg 245	deletion
-	Glu 246	deletion
Ser 122	Gln 248	conflict
Phe 124	Tyr 250	conflict
Pro 125	Thr 251	conflict
Ala 127	Pro 253	conflict
-	Arg 256	deletion
-	Glu 257	deletion
-	Glu 258	deletion
Gly 130	Met 259	conflict
-	Lys 261	deletion
-	Asn 262	deletion
-	Gln 263	deletion
Ala 132	Val 264	conflict
Ala 133	Ser 265	conflict
Gly 135	Thr 267	conflict
Asp 140	Gly 272	conflict
Tyr 141	Phe 273	conflict
Phe 142	Tyr 274	conflict
Glu 144	Ser 276	conflict
Pro 145	Asp 277	conflict
Val 146	Ile 278	conflict
Thr 147	Ala 279	conflict
Ser 149	Glu 281	conflict
Asn 151	Glu 283	conflict
-	Asn 285	deletion
Ala 154	Gln 287	conflict
Leu 155	Pro 288	conflict
Thr 156	Glu 289	conflict
Ser 157	Asn 290	conflict
Gly 158	Asn 291	conflict
Val 159	Tyr 292	conflict
His 160	Lys 293	conflict
Phe 162	Thr 295	conflict
Ala 164	Pro 297	conflict
Gln 167	Asp 300	conflict
Ser 169	Asp 302	conflict
-	Ser 304	deletion
-	Phe 305	deletion
-	Phe 306	deletion
-	Lys 310	deletion
Ser 175	-	expression tag
Ser 176	-	expression tag
Val 177	-	expression tag
Val 178	-	expression tag
Pro 181	Asp 314	conflict
Ser 182	Lys 315	conflict
-	Arg 317	deletion
-	Trp 318	deletion
Ser 184	Gln 319	conflict
Leu 185	Gln 320	conflict
Thr 187	-	expression tag
Gln 188	Asn 322	conflict
Thr 189	Val 323	conflict
Tyr 190	Phe 324	conflict
Ile 191	Ser 325	conflict
Asn 193	Ser 327	conflict
-	Met 329	deletion
-	His 330	deletion
-	Glu 331	deletion
-	Ala 332	deletion
-	Leu 333	deletion
-	His 334	deletion
Lys 197	-	expression tag
Pro 198	-	expression tag
Ser 199	-	expression tag
Asn 200	Tyr 337	conflict
Lys 202	-	expression tag
Val 203	-	expression tag
Asp 204	-	expression tag
Lys 205	-	expression tag
Lys 206	-	expression tag
Val 207	-	expression tag
Glu 208	-	expression tag
Pro 209	Gln 339	conflict
Cys 212	-	expression tag
Asp 213	-	expression tag
Lys 214	-	expression tag
Thr 215	Leu 342	conflict
Thr 217	Leu 344	conflict
Cys 218	Ser 345	conflict
Pro 220	-	expression tag
Cys 221	-	expression tag
Pro 222	-	expression tag
Ala 223	-	expression tag
Pro 224	-	expression tag
Glu 225	-	expression tag
Leu 226	-	expression tag
Leu 227	-	expression tag
Gly 229	Lys 348	conflict

Contents of the asymmetric unit

Polymers	Number of chains	18
	Total formula weight	428576.7
All*	Total formula weight	428576.7

*Water molecules are not included.