4NGB
Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 12-mer siRNA having UU-3' ends (2.25 Angstrom resolution)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Endoribonuclease Dicer | polymer | 302 | 34928.3 | 1 | UniProt (Q9UPY3) Pfam (PF20931) Pfam (PF02170) In PDB | Homo sapiens (human) | Helicase with RNase motif, Helicase MOI |
2 | B | 5'-R(*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3' | polymer | 12 | 3789.3 | 1 | |||
3 | water | water | 18.0 | 194 | Chemie (HOH) |
Sequence modifications
A: 755 - 1055 (UniProt: Q9UPY3)
PDB | External Database | Details |
---|---|---|
Ser 754 | - | expression tag |
Ala 822 | Lys 832 | engineered mutation |
Ala 823 | Lys 833 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 38717.6 | |
All* | Total formula weight | 38717.6 |