4NFN
Human tau tubulin kinase 1 (TTBK1) complexed with 3-({5-[(4-amino-4-methylpiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-bromophenol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tau-tubulin kinase 1 | polymer | 309 | 35464.9 | 1 | UniProt (Q5TCY1) Pfam (PF00069) | Homo sapiens (human) | Brain-derived tau kinase |
| 2 | B (A) | 3-({5-[(4-amino-4-methylpiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-bromophenol | non-polymer | 431.3 | 1 | Chemie (2KC) | |||
| 3 | C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F (A) | water | water | 18.0 | 202 | Chemie (HOH) |
Sequence modifications
A: 14 - 320 (UniProt: Q5TCY1)
| PDB | External Database | Details |
|---|---|---|
| Gly 12 | - | expression tag |
| His 13 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35464.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 719.5 | |
| All* | Total formula weight | 36184.4 |
