4NFN

Human tau tubulin kinase 1 (TTBK1) complexed with 3-({5-[(4-amino-4-methylpiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-bromophenol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 2KC A 401

Chain	Residue
A	ILE48
A	ASP176
A	HOH648
A	ALA61
A	LYS63
A	GLU77
A	VAL105
A	MET107
A	GLN108
A	GLN110
A	ASN159

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 402

Chain	Residue
A	ARG153
A	ARG194
A	ARG200
A	HOH555
A	HOH574
A	HOH653

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 403

Chain	Residue
A	ARG118
A	ARG119
A	ARG204
A	ARG240
A	HOH612

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 404

Chain	Residue
A	ARG57
A	GLY111
A	ARG112
A	ARG164
A	HOH505
A	HOH690

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGGGGFGEIYeAmdlltren..........VALK

Chain	Residue	Details
A	ILE40-LYS63

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	263
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---