4NF6

Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and PPDA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glutamate receptor ionotropic, NMDA 1	polymer	292	33340.0	1	UniProt (P35439) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (rat)	GluN1, Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, NMD-R1
2	B (B)	Glutamate receptor ionotropic, NMDA 2A	polymer	283	31785.3	1	UniProt (Q00959) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (rat)
3	C (A)	GLYCINE	non-polymer		75.1	1	Chemie (GLY)
4	D (B)	(2S,3R)-1-(phenanthren-2-ylcarbonyl)piperazine-2,3-dicarboxylic acid	non-polymer		378.4	1	Chemie (2JL)
5	E, F (A, B)	water	water		18.0	522	Chemie (HOH)

Sequence modifications

A: 2 - 152 (UniProt: P35439)

PDB	External Database	Details
Gly 1	-	expression tag

A: 155 - 292 (UniProt: P35439)

PDB	External Database	Details
Gly 153	-	expression tag
Thr 154	-	expression tag

B: 5 - 142 (UniProt: Q00959)

PDB	External Database	Details
Ser 4	-	expression tag

B: 145 - 286 (UniProt: Q00959)

PDB	External Database	Details
Thr 242	Ser 758	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65125.3
Non-Polymers*	Number of molecules	2
	Total formula weight	453.4
All*	Total formula weight	65578.8

*Water molecules are not included.