4NF4

Crystal structure of GluN1/GluN2A ligand-binding domain in complex with DCKA and glutamate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Glutamate receptor ionotropic, NMDA 1	polymer	292	33340.0	1	UniProt (P35439) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (rat)	GluN1, Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, NMD-R1
2	B	Glutamate receptor ionotropic, NMDA 2A	polymer	283	31785.3	1	UniProt (Q00959) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (rat)
3	A	4-hydroxy-5,7-dimethylquinoline-2-carboxylic acid	non-polymer		217.2	1	Chemie (2JK)
4	B	GLUTAMIC ACID	non-polymer		147.1	1	Chemie (GLU)
5		water	water		18.0	657	Chemie (HOH)

Sequence modifications

A: 2 - 152 (UniProt: P35439)

PDB	External Database	Details
Gly 1	-	EXPRESSION TAG

A: 155 - 292 (UniProt: P35439)

PDB	External Database	Details
Gly 153	-	EXPRESSION TAG
Thr 154	-	EXPRESSION TAG

B: 5 - 142 (UniProt: Q00959)

PDB	External Database	Details
Ser 4	-	EXPRESSION TAG

B: 145 - 286 (UniProt: Q00959)

PDB	External Database	Details
Thr 242	Ser 758	ENGINEERED MUTATION

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65125.3
Non-Polymers*	Number of molecules	2
	Total formula weight	364.4
All*	Total formula weight	65489.7

*Water molecules are not included.