4NDI
Human Aprataxin (Aptx) AOA1 variant K197Q bound to RNA-DNA, AMP, and Zn - product complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Aprataxin | polymer | 182 | 21258.7 | 2 | UniProt (Q7Z2E3) Pfam (PF11969) Pfam (PF16278) | Homo sapiens (human) | Forkhead-associated domain histidine triad-like protein, FHA-HIT |
| 2 | C, E (D, G) | 5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3' | polymer | 10 | 3066.0 | 2 | |||
| 3 | D, F (E, H) | 5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3' | polymer | 10 | 3037.0 | 2 | |||
| 4 | G, L (A, B) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (40467049) PubChem (40469468) PubChem (44348067) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (46875232) PubChem (177678969) PubChem (6083) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (1549371) PubChem (92144436) PubChem (224) PubChem (12358354) PubChem (34768) PubChem (83862) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (122197642) PubChem (5316444) PubChem (5742864) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 5 | H, M (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | I (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 7 | J, N (A, B) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 2 | Chemie (BME) | |||
| 8 | K (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 9 | O, P (D, G) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) PubChem (813) | |||
| 10 | Q, R, S, T, U... (A, B, D, E, G...) | water | water | 18.0 | 698 | Chemie (HOH) |
Sequence modifications
A, B: 165 - 342 (UniProt: Q7Z2E3)
| PDB | External Database | Details |
|---|---|---|
| Gly 161 | - | expression tag |
| Ser 162 | - | expression tag |
| His 163 | - | expression tag |
| Met 164 | - | expression tag |
| Gln 197 | Lys 211 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 54723.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1174.8 | |
| All* | Total formula weight | 55898.3 |
